Ammonium Hydroxide → HCID 67849121, compound

HRID 1033908Notes

Reaction equation

HRID 1033908 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[N+:29]([O-:31])=[O:30])[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)/[C:12](O)=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].S(Cl)(Cl)=O.[OH-].[NH4+:37]>>[CH2:1]([C:5]1[N:6]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[N+:29]([O-:31])=[O:30])[C:7](/[CH:10]=[C:11](\[CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)/[C:12]([NH2:37])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 24386Thionyl ChlorideHCID 19024583HCID 19024583, compound

Product 1

HCID 67849121HCID 67849121, compound

Procedure

(E)-3-[2-n-Butyl-1-{(2-nitrophenyl)methyl}-1H-imidazol-5yl]-2-benzyl-2-propenoic acid, prepared in Example 58, is treated with thionyl chloride and then ammonium hydroxide, as described in Example 57, to give the title compound.

Sources & evidence

ORD record
ord-f6a49760e1f24094983e83f78750f494
Source dataset
uspto-grants-1994_05
Patent number
US05312828

Reaction notes

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