反应详情

温度

25 °C

To a solution of 1-(2-methyl-l-propenyl)-3-nitrobenzene (4.57 g) in a mixture of methanol (50 ml) and 6N hydrochloric acid (14 ml) was added 10% palladium on activated carbon (1 g), and the mixture was stirred under hydrogen atmosphere (3 atm) at 25° C. for 3 hours. The catalyst was filtered off, and the filtrate was evaporated. The residue was poured into a mixture of ethyl acetate and aqueous sodium bicarbonate. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. Evaporation of the solvent gave 3-isobutylphenylamine (3.98 g) as a brown oil.

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated
3. additionThe residue was poured into a mixture of ethyl acetate and aqueous sodium bicarbonate
4. customThe organic layer was separated
5. washwashed with water and brine
6. dry with materialdried over magnesium sulfate
7. customEvaporation of the solvent