反应详情

4'-Isobutylpentanophenone (2.1 g) was added to a solution of (+)-B-chlorodiisopinocampheylborane (3.57 g) in tetrahydrofuran (7 ml) at -25° C. After stirring for 5 hours, the solvent was removed and the residue was dissolved in ethyl ether (30 ml). To this solution was added diethanolamine (2 ml), and the mixture was stirred for 2 hours. The solid was filtered off and washed with ethyl ether. The combined filtrates were concentrated and the residue was chromatographed on silica gel (hexane:dichloromethane =1:2) to give (R)-1-(4-isobutylphenyl)pentan-1-ol (635 mg).

1. customthe solvent was removed
2. dissolutionthe residue was dissolved in ethyl ether (30 ml)
3. additionTo this solution was added diethanolamine (2 ml)
4. stirringthe mixture was stirred for 2 hours
5. filtrationThe solid was filtered off
6. washwashed with ethyl ether
7. concentrationThe combined filtrates were concentrated
8. customthe residue was chromatographed on silica gel (hexane:dichloromethane =1:2)