反应详情

温度

-78 °C

Under nitrogen flow, the 27 g of 4-propyl-β,β-dibromostyrene was dissolved in 44 ml of tetrahydrofuran and cooled to -78° C. Two hundred ml of a butyl lithium hexane solution (1.6 mol/1 was added dropwise therein over a period of one hour. The solution was then agitated at room temperature for one and a half hours. After completion of the reaction, 200 ml of water was added. The crystals then were extracted with chloroform and washed three times with water. The remaining chloroform was distilled off, after which vacuum distillation (70° to 75° C./20 mmHg) was carried out to obtain 3.5 g of 4-propylphenylacetylene.

1. additionwas added
2. extractionThe crystals then were extracted with chloroform
3. washwashed three times with water
4. distillationThe remaining chloroform was distilled off
5. distillationafter which vacuum distillation (70° to 75° C./20 mmHg)