Aluminum(III) Chloride → 1-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine

HRID 1034199Notes

Reaction equation

HRID 1034199 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:11]1[C:15]2([CH2:20][CH2:19][CH2:18][CH:17]([C:21]([N:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH2:25][CH2:24]3)=O)[CH2:16]2)[O:14][CH2:13][CH2:12]1>>[O:11]1[C:15]2([CH2:20][CH2:19][CH2:18][CH:17]([CH2:21][N:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=4)[CH2:25][CH2:24]3)[CH2:16]2)[O:14][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 200766821-(1,4-Dioxaspiro[4.5]dec-7-ylcarbonyl)-4-(2-pyridinyl)piperazineHCID 21226445Aluminium lithium hydride

Product 1

HCID 200767021-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazineYield 92.6%

Procedure

From aluminum chloride (5.39 g), lithium aluminum hydride (4.61 g) and 1-(1,4-dioxaspiro[4.5]dec-7-ylcarbonyl)-4-(2-pyridinyl)piperazine (40.22 g) (Step A) using the procedure of Example A, Step C is obtained 35.66 g of the title compound as an oil.

Sources & evidence

ORD record
ord-2408833dcde241049d8f6e7c6bf5d311
Source dataset
uspto-grants-1994_05
Patent number
US05314896

Reaction notes

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