HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine → 3-[[4-(2-Pyridinyl)piperazinyl]methyl]cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine | HCID 20076702 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-[[4-(2-Pyridinyl)piperazinyl]methyl]cyclohexanone | HCID 15294399 | 88.5% |
Reaction Steps
From 1-(1,4-dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine (Step B) (8.4 g) and 50 mL of 10% aqueous hydrochloric acid solution using the procedure of Example A, Step D is obtained 6.4 g of the title compound as a white solid; mp 86°-90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05314896 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-66b33b08caef4eb385ee0f488e27e4f1 |
| Source note | uspto-grants-1994_05 |