1-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine → 3-[[4-(2-Pyridinyl)piperazinyl]methyl]cyclohexanone

HRID 1034200Notes

Reaction equation

HRID 1034200 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH2:8][CH:7]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[CH2:6]2)[O:4]CC1>Cl>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[N:15]1[CH2:16][CH2:17][N:12]([CH2:11][CH:7]2[CH2:8][CH2:9][CH2:10][C:5](=[O:4])[CH2:6]2)[CH2:13][CH2:14]1

Participants

3

Reactant 1

HCID 200767021-(1,4-Dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine

Product 1

HCID 152943993-[[4-(2-Pyridinyl)piperazinyl]methyl]cyclohexanoneYield 88.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

From 1-(1,4-dioxaspiro[4.5]dec-7-ylmethyl)-4-(2-pyridinyl)piperazine (Step B) (8.4 g) and 50 mL of 10% aqueous hydrochloric acid solution using the procedure of Example A, Step D is obtained 6.4 g of the title compound as a white solid; mp 86°-90° C.

Sources & evidence

ORD record
ord-66b33b08caef4eb385ee0f488e27e4f1
Source dataset
uspto-grants-1994_05
Patent number
US05314896

Reaction notes

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