HCID 19023733, compound → 1,2-Benzenediamine, N1-[(4-chlorophenyl)methyl]-4-(trifluoromethyl)-, hydrochloride (1:1)

HRID 1034211Notes

Reaction equation

HRID 1034211 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][NH:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[N+:18]([O-])=O)=[CH:4][CH:3]=1>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][NH:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:16])[F:17])=[CH:10][C:9]=2[NH2:18])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 19023733HCID 19023733, compound

Product 1

HCID 190237371,2-Benzenediamine, N1-[(4-chlorophenyl)methyl]-4-(trifluoromethyl)-, hydrochloride (1:1)

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(4-chlorobenzylamino)-5-trifluoromethylnitrobenzene (70 g, 0.21 mmol) in ethanol (500 ml) was hydrogenated at a pressure of 4 bar. When the reaction was finished the product was filtered through a plug of celite into a flask containing 25 ml conc. HCl. After evaporation the product was suspended in petrol ether and filtered off. Yield 57 g.

Workup

  1. filtrationwas filtered through a plug of celite into a flask
  2. additioncontaining 25 ml conc. HCl
  3. customAfter evaporation the product
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-8dd7fe7d9ea3452e82d9b0e42f55e7ce
Source dataset
uspto-grants-1994_05
Patent number
US05314903

Reaction notes

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