Water → HCID 73509150, compound

HRID 1034226Notes

Reaction equation

HRID 1034226 reaction equation
O[C:2]1[C:6](=[O:7])[N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][C:3]=1[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].Cl.[NH2:23][OH:24].O>N1C=CC=CC=1>[OH:24][N:23]=[C:2]1[C:6](=[O:7])[N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH:3]1[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]

Participants

5

Reactant 3

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 54691691HCID 54691691, compound

Product 1

HCID 73509150HCID 73509150, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of the title compound of Example I (8.07 g, 27.9 mmol) in 150 ml of pyridine was added hydroxylamine hydrochloride (9.69 g, 139 mmol) and resulting solution was stirred for 4 d. Addition of H2O resulted in the formation of precipitate which was filtered to give the title compound (7.11 g, 84%) as a colorless solid. Calculated for C16H20N2O4 1/2H2O: C, 61.35; H, 6.76; N, 8.94. Found C, 61.35; H, 6.57, N, 9.34.

Workup

  1. customresulting solution
  2. customresulted in the formation of precipitate which
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-2f8fd25008ba4890bd3938386d02e139
Source dataset
uspto-grants-1994_05
Patent number
US05314886

Reaction notes

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