Dichloromethane → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7,8-difluoroquinoxalin-2(1H)-one

HRID 103424Notes

Reaction equation

HRID 103424 reaction equation
[Cl:58][CH2:59][Cl:60].[F:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][c:8](=[O:29])[n:9]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:10]2[c:11]1[F:12].[NH2:37][CH:38]1[CH2:39][CH2:40][N:41]([CH2:42][CH2:43][n:44]2[c:45]3[c:46]([cH:47][cH:48][c:49]([F:50])[cH:51]3)[n:52][cH:53][c:54]2=[O:55])[CH2:56][CH2:57]1.[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[F:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][c:8](=[O:29])[n:9]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:10]2[c:11]1[F:12]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 593979071-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-oneHCID 86642645tert-Butyl{1-[2-(7,8-difluoro-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667751791-[2-(4-Aminopiperidin-1-yl)ethyl]-7,8-difluoroquinoxalin-2(1H)-one

Sources & evidence

ORD record
ord-4aaa593de1a041b1aa0253d9cf8cd5f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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