HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Mercaptobenzoic Acid → HCID 19023680, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| Reactant | 3-[1-(4-Chlorobenzyl)-3-(t-butylthio)-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid methyl ester | HCID 11762500 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 19023680 | HCID 19023680 | — |
Reaction Steps
A mixture of the product from Step 1 (2.03 g, 4.29 mmol) and thiosalicylic acid (1.32 g, 8.58 mmol) in TFA (25 mL) was refluxed for 2.5 hours. The TFA was evaporated, the residue was diluted with EtOAc, washed twice with 1N aq NaOH, then 3× with H2O, dried and evaporated to afford the crude title product as a thick oil which was taken as such into the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05314898 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-eef482d2ece7407dad948dc4a4163547 |
| Source note | uspto-grants-1994_05 |