反应详情

A mixture of the product from Step 1 (2.03 g, 4.29 mmol) and thiosalicylic acid (1.32 g, 8.58 mmol) in TFA (25 mL) was refluxed for 2.5 hours. The TFA was evaporated, the residue was diluted with EtOAc, washed twice with 1N aq NaOH, then 3× with H2O, dried and evaporated to afford the crude title product as a thick oil which was taken as such into the next step.

1. temperaturewas refluxed for 2.5 hours
2. customThe TFA was evaporated
3. additionthe residue was diluted with EtOAc
4. washwashed twice with 1N aq NaOH
5. dry with material3× with H2O, dried
6. customevaporated