Ammonia → Carbon Dioxide

HRID 1034405Notes

Reaction equation

[O:1]=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.N.N[C@H:15]([C:20]([OH:22])=[O:21])[CH2:16][C:17]([OH:19])=[O:18]>>[C:17](=[O:19])=[O:18].[C:15]([CH2:16][C:17]([O-:19])=[O:18])([C:20]([OH:22])=[O:21])=[O:1]

Participants

Reactant 3

HCID 222Ammonia

HCID 5960L-Aspartic Acid

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

Product 2

HCID 280Carbon Dioxide

HCID 3260017Oxaloacetate Ion

Procedure

The present invention provides an enzymatic or microbial bioconversion process that is capable of producing L-amino acids from the corresponding racemic mixture or from purely D-amino acid sources. The invention utilizes a transaminase that is moderately selective in the conversion of D and L amino acids to 2-keto acids, but exhibits absolute stereospecificity in the conversion of 2-keto acids to L-amino acids. Hence, a D amino acid or a D, L mixture of an amino acid can react with a) glucose and ammonia or b) aspartic acid in the presence of a transaminase to produce the corresponding L-amino acid and c) carbon dioxide or d) oxaloacetate.

Workup

customThe present invention provides an enzymatic or microbial bioconversion process that

Sources & evidence

ORD record: ord-4bbf9ec66d7a47c8877596c2de78bf2b
Source dataset: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05316943

Reaction notes

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