HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-Chloropyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 6-Chloro-2-nitropyridin-3-amine | HCID 19022792 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Chloropyridine-2,3-diamine | HCID 10630615 | 79.5% |
Reaction Steps
A solution of tin (II) chloride (21.8 g) in concentrated hydrochloric acid (30 ml) was added, with cooling, to 6-chloro-3-amino-2-nitropyridine (5 g) and the suspension stirred for 3 hours at room temperature. The pH was adjusted to pH12 (40% NaOH) and the solvent removed in vacuo. The residue was purified by flash column chromatography, eluting with System C (100:8:1), to afford the title compound as a yellow solid (3.29 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05317023 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-cd53c226bebf4e1c924f09eb8582b479 |
| Source note | uspto-grants-1994_05 |