反应详情

A solution of tin (II) chloride (21.8 g) in concentrated hydrochloric acid (30 ml) was added, with cooling, to 6-chloro-3-amino-2-nitropyridine (5 g) and the suspension stirred for 3 hours at room temperature. The pH was adjusted to pH12 (40% NaOH) and the solvent removed in vacuo. The residue was purified by flash column chromatography, eluting with System C (100:8:1), to afford the title compound as a yellow solid (3.29 g).

1. customthe solvent removed in vacuo
2. customThe residue was purified by flash column chromatography
3. washeluting with System C (100:8:1)