反应详情

Succinic anhydride (0.60 g, 5.99 mmol, 1.1 equiv) was added in one portion to a dry THF (11 mL) solution of 1-(dimethylamino)-4-((9Z,12Z)-octadeca-9,12-dienyloxy)butan-2-ol (2.0 g, 5.45 mmol, 1.0 equiv) and the resultant was refluxed for 18 hours under argon. The mixture was concentrated and the residue was partitioned between EtOAc (10 mL) and deionized water (20 mL). The layers were separated and the aqueous layer was extracted with two additional portions of EtOAc (25 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated to provide crude 4-(1-(dimethylamino)-4-((9Z,12Z)-octadeca-9,12-dienyloxy)butan-2-yloxy)-4-oxobutanoic acid, a thick, yellow oil, which was used without further purification.

1. temperaturethe resultant was refluxed for 18 hours under argon
2. concentrationThe mixture was concentrated
3. customthe residue was partitioned between EtOAc (10 mL) and deionized water (20 mL)
4. customThe layers were separated
5. extractionthe aqueous layer was extracted with two additional portions of EtOAc (25 mL)
6. dry with materialThe combined organic extracts were dried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated