Hydrochloric Acid → HCID 131730881, compound

Participants

Reaction Steps

The obtained compound (1) (10.0 g, 33 mmol) was dissolved in methanol (150 mL), and 1 N aqueous sodium hydroxide (33 mL, 33 mmol) was further added thereto, and then the mixture was reacted at room temperature for 3 hours with stirring. After completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid, and objective substance was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3). The extracted objective substance was concentrated under reduced pressure and dried, to obtain Boc-Thr-Gly-OH (2) (5.4 g) (yield; 60.2%).

Provenance & Evidence