Hydrochloric Acid → HCID 131730881, compound

HRID 1034562Notes

Reaction equation

HRID 1034562 reaction equation
[NH:1]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@H:2]([C:6]([NH:8][CH2:9][C:10]([O:12]CC)=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4].[OH-].[Na+].Cl>CO>[NH:1]([C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16])[C@H:2]([C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131730880HCID 131730880, compound

Product 1

HCID 131730881HCID 131730881, compoundYield 60.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The obtained compound (1) (10.0 g, 33 mmol) was dissolved in methanol (150 mL), and 1 N aqueous sodium hydroxide (33 mL, 33 mmol) was further added thereto, and then the mixture was reacted at room temperature for 3 hours with stirring. After completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid, and objective substance was extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3). The extracted objective substance was concentrated under reduced pressure and dried, to obtain Boc-Thr-Gly-OH (2) (5.4 g) (yield; 60.2%).

Workup

  1. customthe mixture was reacted at room temperature for 3 hours
  2. customAfter completion of the reaction
  3. extractionwas extracted with a mixed solvent of ethyl acetate and n-butanol (mixing ratio=7:3)
  4. concentrationThe extracted objective substance was concentrated under reduced pressure
  5. customdried

Sources & evidence

ORD record
ord-d3b1878ee84d47238ff7abb102831335
Source dataset
uspto-grants-2013_10
Patent number
US08546072B2

Reaction notes

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