反应详情

温度

0 °C

25 g of (R)-2-ethoxycarbonylmethyl-4-hydroxy-2-cyclopenten-1-one (5 g, 98% e.e.) was dissolved in ethyl acetate and the solution was placed in a nitrogen purged flask. Imidazole (13.87 g, 204 mmol) was added. The solution was cooled to 0° C. and triethylchlorosilane (26.6 g, 176 mmol) was added slowly. The reaction mixture was allowed to warm to room temperature and stirred for another 15 hours. After filtration, the filtrate was washed with a saturated sodium bicarbonate solution and a brine solution, respectively, dried over anhydrous magnesium sulfate, and concentrated to obtain the titled compound (38.5 g, 95%). [α]D: +27.8° (c 1.0, CH3CN).

1. customthe solution was placed in a nitrogen purged flask
2. temperatureto warm to room temperature
3. filtrationAfter filtration
4. washthe filtrate was washed with a saturated sodium bicarbonate solution
5. dry with materiala brine solution, respectively, dried over anhydrous magnesium sulfate
6. concentrationconcentrated