Hydrochloric Acid → HCID 44246618, compound

HRID 1034603Notes

Reaction equation

HRID 1034603 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[OH-].[Na+].Cl>CO>[CH2:15]([O:14][C:10]1[N:9]=[CH:8][N:7]=[C:6]2[C:11]=1[N:12]=[CH:13][N:5]2[CH2:4][C:3]([OH:22])=[O:2])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59289995Methyl [6-(benzyloxy)-9H-purin-9-yl]acetate

Product 1

HCID 44246618HCID 44246618, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl(6-(Benzyloxy)purin-9-yl)acetate (2.10 g; 7.0 mmol) was dissolved in methanol (70 ml) and 0.1 M NaOH (85 ml) is added. After 15 min. the pH of the reaction mixture was lowered by addition of 0.1 M HCl (˜80 ml) to pH 3. The precipitate was separated from the mixture by filtration and washed with water and ether. Yield: 1.80 g (90.2%). 1H-NMR (DMSO-d6): 8.55 (1H, s); 8.37 (1H, s); 7.55-7.30 (5H, m); 5.64 (2H, s); 5.09 (2H, s).

Workup

  1. customThe precipitate was separated from the mixture by filtration
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-ceecc3ac0acb428ba9a3710979877d66
Source dataset
uspto-grants-2013_10
Patent number
US08546309B2

Reaction notes

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