Hexachloroethane → 5-Chloro-4-fluoro-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine

HRID 1034652Notes

Reaction equation

HRID 1034652 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([Si:11]([CH:18]([CH3:20])[CH3:19])([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:10][C:3]=12.[Li]C(CC)C.[Cl:26]C(Cl)(Cl)C(Cl)(Cl)Cl>C1COCC1>[Cl:26][C:7]1[C:2]([F:1])=[C:3]2[CH:10]=[CH:9][N:8]([Si:11]([CH:15]([CH3:17])[CH3:16])([CH:18]([CH3:20])[CH3:19])[CH:12]([CH3:13])[CH3:14])[C:4]2=[N:5][CH:6]=1

Participants

5

Reactant 3

HCID 6214HexachloroethaneHCID 112663344-Fluoro-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineHCID 178418400CID 53628100

Product 1

HCID 602052735-Chloro-4-fluoro-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineYield 62.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (3.0 g, 10.258 mmol) was placed in THF (15 mL) at −78° C. s-BuLi (16.12 mL, 22.57 mmol) was then added dropwise and stirred for 30 minutes. Hexachloroethane (6.07 g, 25.6 mmol) in THF (10 mL) was then added rapidly, and the reaction was stirred for an additional 30 minutes. The reaction was quenched with saturated aqueous NH4Cl and extracted into hexanes. The combined organic fractions were dried, filtered and concentrated to give the crude product that was purified by column chromatography (hexanes) to give 5-chloro-4-fluoro-1-(tri isopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (2.1 g, 62% yield).

Workup

  1. additionwas then added dropwise
  2. stirringthe reaction was stirred for an additional 30 minutes
  3. customThe reaction was quenched with saturated aqueous NH4Cl
  4. extractionextracted into hexanes
  5. customThe combined organic fractions were dried
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customto give the crude product that
  9. customwas purified by column chromatography (hexanes)

Sources & evidence

ORD record
ord-dd795937dc3341e18026045bceb1a618
Source dataset
uspto-grants-2013_10
Patent number
US08545897B2

Reaction notes

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