反应详情

A solution of EXAMPLE 24B (1.9 g, 7 mmol) and methylhydrazine (367 μL, 7 mmol) in ethanol (15 mL) was heated at reflux for 4 hours. After cooling, the mixture was concentrated and the residue purified by flash chromatography on silica gel using 0-15% methanol in dichloromethane to give the title compound (1.78 g, 85%). MS(DCI): m/z 301 (M+1)+.

1. temperatureat reflux for 4 hours
2. temperatureAfter cooling
3. concentrationthe mixture was concentrated
4. customthe residue purified by flash chromatography on silica gel using 0-15% methanol in dichloromethane