Methylhydrazine → benzyl 3-(5-amino-1-methyl-1H-pyrazol-3-yl)-pyrrolidine-1-carboxylate

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Reaction Steps

A solution of EXAMPLE 24B (1.9 g, 7 mmol) and methylhydrazine (367 μL, 7 mmol) in ethanol (15 mL) was heated at reflux for 4 hours. After cooling, the mixture was concentrated and the residue purified by flash chromatography on silica gel using 0-15% methanol in dichloromethane to give the title compound (1.78 g, 85%). MS(DCI): m/z 301 (M+1)+.

Provenance & Evidence