3-Hydroxypyridine → 6-Methyl-2-(pyridin-3-yloxy)-nicotinonitrile

HRID 1035003Notes

Reaction equation

HRID 1035003 reaction equation
Cl[C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=1>>[CH3:10][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([O:17][C:13]2[CH:12]=[N:11][CH:16]=[CH:15][CH:14]=2)[N:9]=1

Participants

3

Reactant 2

HCID 79713-HydroxypyridineHCID 5204002-Chloro-6-methylpyridine-3-carbonitrile

Product 1

HCID 552074746-Methyl-2-(pyridin-3-yloxy)-nicotinonitrile

Procedure

2-chloro-6-methyl-nicotinonitrile was reacted with pyridin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 212(M+1)+.

Sources & evidence

ORD record
ord-1c0a4c66e7844ecc8217d2b239da91e6
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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