2,3-Bis(trifluoromethyl)aniline → 1-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thiourea

HRID 1035095Notes

Reaction equation

HRID 1035095 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:13].[F:16][C:17]1[C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=[CH:19][N:18]=1.ClC1C(Cl)=CC=CC1(N=[C:35]=[S:36])F>>[F:1][C:2]([F:14])([F:15])[C:3]1[C:8]([C:9]([F:11])([F:12])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH:13][C:35]([NH:24][CH2:23][C:22]1[C:17]([F:16])=[N:18][CH:19]=[CH:20][CH:21]=1)=[S:36]

Participants

4

Reactant 3

HCID 199806622,3-Bis(trifluoromethyl)anilineHCID 45079719(2-Fluoropyridin-3-yl)methanamineHCID 866035332,3-Dichloro-1-fluorophenylisothiocyanate

Product 1

HCID 866035321-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thioureaYield 90%

Procedure

Prepared in 90% yield from the product of Example 197A and the product of Example 193C according to the procedure described for the product of Example 192D and Example 192G.

Sources & evidence

ORD record
ord-838514b9f9e14467ac8ce1415ec270e8
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

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