2-Fluoropyridine-3-boronic acid → HCID 68584668, compound

HRID 1035107Notes

Reaction equation

HRID 1035107 reaction equation
[F:1][C:2]1[C:7](B(O)O)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:12]1[C:17]([CH2:18][NH:19][C:20]2[N:24]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[C:27]([Cl:32])[C:26]=3[Cl:33])[N:23]=[N:22][N:21]=2)=[CH:16][CH:15]=[CH:14][N:13]=1>>[Cl:33][C:26]1[C:27]([Cl:32])=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[N:24]1[C:20]([NH:19][CH2:18][C:17]2[C:12]([C:7]3[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=3)=[N:13][CH:14]=[CH:15][CH:16]=2)=[N:21][N:22]=[N:23]1

Participants

3

Reactant 2

HCID 27832702-Fluoropyridine-3-boronic acidHCID 59264553HCID 59264553, compound

Product 1

HCID 68584668HCID 68584668, compound

Procedure

The title compound was prepared from 2-fluoropyridine-3-boronic acid and the product of Example 285B using General Procedure 6. MS (ESI+) m/z 434.2 (M+H)+; Rt=1.87 min. 1H-NMR (400 MHz, DMSO-d6) δ 5.56 (s, 2H), 7.46 (m, 2H), 7.55 (m, 2H), 7.73 (dd, J=1.5 Hz, J=7.9 Hz, 1H), 7.98 (ddd, J=2.0 Hz, J=7.4 Hz, J=9.6 Hz, 1H), 8.31 (d, J=4.8 Hz, 1H), 8.68 (dd, J=1.61 Hz, J=4.7 Hz, 1H), 8.99 (s, 1H).

Sources & evidence

ORD record
ord-7c2aad948d844cb8a259845a76f9bdbb
Source dataset
uspto-grants-2013_10
Patent number
US08546374B2

Reaction notes

Loading…