HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 1-(4-(Azetidin-3-yloxy)benzyl)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | tert-Butyl 3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidine-1-carboxylate | HCID 58043102 | — |
| Reactant | 1-(4-(Azetidin-3-yloxy)-2-methylphenyl)-N,N-dimethylmethanamine | HCID 66656350 | — |
| Product | 1-(4-(Azetidin-3-yloxy)benzyl)azetidine | HCID 66653495 | 39% |
Reaction Steps
Using similar protocols as described in Examples 20A, 20B and 20C employing azetidine and 4-hydroxybenzaldehyde as starting material afforded 0.44 g (39%) of 41A as an oil. 1H NMR (500 MHz, CDCl3): δ 2.06 (m, 2H), 3.18 (m, 4H), 3.35 (t, 1H), 3.48 (s, 2H), 3.66 (t, 1H), 3.8-5.0 (m, 3H), 6.71 (m, 2H), 7.16 (d, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546375B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-48605add3136462ebe946ee8f998c2a6 |
| Source note | uspto-grants-2013_10 |