HRID1035212

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53167

1-Methylpiperazine

C5H12N2

HCID185363

2-Chloro-4-hydroxybenzaldehyde

C7H5ClO2

结构：Cc1cc(OC2CN(C(=O)OC(C)(C)C)C2)ccc1CN(C)C

HCID58043102

1-Azetidinecarboxylic acid, 3-[4-[(dimethylamino)methyl]-3-methylphenoxy]-, 1,1-dimethylethyl ester

C18H28N2O3

HCID66656350

未命名化合物

PRODUCTS

生成物

HCID66653266

未命名化合物

收率 32%

PROCEDURE

实验过程

Using similar protocols as described in Examples 20A, 20B and 20C employing 1-methylpiperazine and 2-chloro-4-hydroxybenzaldehyde as starting material afforded 0.32 g (32%) of 49A as an oil. 1H NMR (500 MHz, CDCl3): δ 2.29 (s, 3H), 2.3-2.7 (m, 8H), 3.55 (s, 2H), 3.78 (m, 2H), 3.92 (m, 2H), 4.96 (m, 1H), 6.64 (d, 1H), 6.74 (d, 1H), 7.31 (m, 1H), MS (APCI+) m/z 296 [M+H]+.