Trifluoroacetic acid → 1354792-80-5

HRID 1035238Notes

Reaction equation

HRID 1035238 reaction equation
[CH2:1]([C:3]1([OH:14])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)[CH3:2].[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16].[CH2:1]([C:3]1([OH:14])[CH2:6][NH:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 45094616Tert-butyl 3-ethyl-3-hydroxyazetidine-1-carboxylate

Product 1

HCID 666534471354792-80-5Yield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 3-ethyl-3-hydroxyazetidine-1-carboxylate (2.3 g, 11.43 mmol) was dissolved in DCM (10 mL) and TFA (15 mL) was added. The reaction mixture was stirred at RT for 2.5 h and then the mixture was evaporated. Ethanol was added and the mixture was again evaporated to afford 3.0 g (100%) of 70A. 1H NMR (500 MHz, CDCl3): δ 0.96 (t, 3H), 1.81 (q, 2H), 3.94 (m, 4H).

Workup

  1. customthe mixture was evaporated
  2. additionEthanol was added
  3. customthe mixture was again evaporated

Sources & evidence

ORD record
ord-3f62a822d3da40c5a53180ab38e47ed6
Source dataset
uspto-grants-2013_10
Patent number
US08546375B2

Reaction notes

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