3-Chloro-4-hydroxybenzaldehyde → 3-Chloro-4-(1-(5-phenyl-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yloxy)benzaldehyde

Participants

Reaction Steps

Using a similar protocol as described in Example 71A employing 53B and 3-chloro-4-hydroxybenzaldehyde as starting materials afforded 51 mg (10%) of 78A as a solid. 1H NMR (500 MHz, CDCl3): δ 4.44 (m, 1H), 4.75 (m, 1H), 4.87 (m, 1H), 5.22 (m, 2H), 6.75 (s, 1H), 7.53 (t, 2H), 7.61 (t, 1H), 7.80 (d, 1H), 7.98 (s, 1H), 8.18 (d, 2H), 9.90 (s, 1H).

Provenance & Evidence