3-Chloro-4-hydroxybenzaldehyde → 3-Chloro-4-(1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yloxy)benzaldehyde

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Reaction Steps

Using a similar protocol as described in Example 71A employing 73B and 3-chloro-4-hydroxybenzaldehyde as starting materials afforded 80 mg (15%) of 79A as a solid. 1H NMR (500 MHz, CDCl3): δ 3.89 (s, 3H), 4.43 (m, 1H), 4.74 (m, 1H), 4.85 (m, 1H), 5.21 (m, 2H), 6.75 (s, 1H), 7.02 (d, 2H), 7.79 (d, 1H), 7.97 (s, 1H), 8.11 (d, 2H), 9.89 (s, 1H).

Provenance & Evidence