Hydrochloric Acid → (3-Methylpyrrolidin-3-yl)methanol hydrochloride

HRID 1035256Notes

Reaction equation

HRID 1035256 reaction equation
[OH:1][CH2:2][C:3]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.CO.[ClH:18]>>[ClH:18].[CH3:15][C:3]1([CH2:2][OH:1])[CH2:7][CH2:6][NH:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 597084561-Boc-3-methylpyrrolidine-3-methanol

Product 1

HCID 66653455(3-Methylpyrrolidin-3-yl)methanol hydrochloride

Procedure

tert-butyl 3-(hydroxymethyl)-3-methylpyrrolidine-1-carboxylate (0.31 g, 1.44 mmol, see WO 2009132986) was dissolved in HCl in methanol (1.25M, 3.5 mL, 4.32 mmol). The reaction mixture was stirred at RT overnight and then the mixture was evaporated. Ethanol was added and the mixture was again evaporated to afford 243 mg. The crude product was used in the next step without further purification.

Workup

  1. customthe mixture was evaporated
  2. additionEthanol was added
  3. customthe mixture was again evaporated
  4. customto afford 243 mg
  5. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-6b9f9abe7b2e4461acffaa9c909ff603
Source dataset
uspto-grants-2013_10
Patent number
US08546375B2

Reaction notes

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