反应详情

tert-butyl 3-(hydroxymethyl)-3-methylpyrrolidine-1-carboxylate (0.31 g, 1.44 mmol, see WO 2009132986) was dissolved in HCl in methanol (1.25M, 3.5 mL, 4.32 mmol). The reaction mixture was stirred at RT overnight and then the mixture was evaporated. Ethanol was added and the mixture was again evaporated to afford 243 mg. The crude product was used in the next step without further purification.

1. customthe mixture was evaporated
2. additionEthanol was added
3. customthe mixture was again evaporated
4. customto afford 243 mg
5. customThe crude product was used in the next step without further purification