Methylamine → HCID 46901760, compound

HRID 1035394Notes

Reaction equation

HRID 1035394 reaction equation
[CH3:1][NH2:2].Cl[C:4]1[N:9]=[C:8]2[N:10]=[CH:11][CH:12]=[C:13]([O:14][C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[C:17]([F:29])[CH:16]=3)[C:7]2=[N:6][CH:5]=1>>[F:29][C:17]1[CH:16]=[C:15]([O:14][C:13]2[C:7]3[C:8](=[N:9][C:4]([NH:2][CH3:1])=[CH:5][N:6]=3)[N:10]=[CH:11][CH:12]=2)[CH:20]=[CH:19][C:18]=1[NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 46899947HCID 46899947, compound

Product 1

HCID 46901760HCID 46901760, compound

Procedure

Method D6 was used with methylamine and Tert-butyl 4-(3-chloropyrido[2,3-b]pyrazin-8-yloxy)-2-fluorophenylcarbamate to give the title compound as a white solid. Yield: 80 mg (90%).

Sources & evidence

ORD record
ord-ea7e4133fcdc4fab9c64b2932a5ab9ba
Source dataset
uspto-grants-2013_10
Patent number
US08546387B2

Reaction notes

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