反应详情

温度

60 °C

8.6 0.003 ml (0.06 mmol) of hydrazinium hydroxide is added at RT to a solution of 29 mg (0.06 mmol) of 2-(3-{2-amino-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrimidin-4-yl]propyl)isoindole-1,3-dione in 0.5 ml of methanol. The reaction solution is heated for 5 min at 60° C. in the microwave. The reaction mixture is evaporated in vacuo, and the residue is purified by preparative HPLC, giving 4-(3-aminopropyl)-6-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-ylamine as yellow solid, ESI 349

1. customThe reaction mixture is evaporated in vacuo
2. customthe residue is purified by preparative HPLC