HRID1035486

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID787

Hydroxylamine

H3NO

结构：O=[N+]([O-])c1c(OCc2ccccc2)nc2ccccc2c1Cl

HCID21075762

未命名化合物

结构：O=[N+]([O-])c1c(OCc2ccccc2)nc2cccnc2c1Cl

HCID66650176

未命名化合物

PRODUCTS

生成物

结构：Nc1c([N+](=O)[O-])c(OCc2ccccc2)nc2cccnc12

HCID66649873

未命名化合物

结构：Nc1c([N+](=O)[O-])c(OCc2ccccc2)nc2ccccc12

HCID66649911

未命名化合物

PROCEDURE

实验过程

In step (5) of Reaction Scheme IV, a benzyloxy-4-chloro-3-nitroquinoline or benzyloxy-4-chloro-3-nitro[1,5]naphthyridine of Formula XXXIX is treated with an amino alcohol of Formula XVI to provide a benzyloxy-3-nitroquinolin-4-amine or benzyloxy-3-nitro[1,5]naphthyridin-4-amine of Formula XL. The reaction is conveniently carried out according to the methods described in step (1) of Reaction Scheme I.

WORKUP

后处理

customIn step (5) of Reaction Scheme IV

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8f72ee50cba74113aea4611ab4fdf0d5
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546383B2
来源说明: uspto-grants-2013_10

反应 SMILES

[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17](Cl)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39](Cl)[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.NO>>[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17]([NH2:32])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39]([NH2:10])[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1