HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 1,6-Dibromo-2-methoxynaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Bromo-6-methoxynaphthalene | HCID 78786 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,6-Dibromo-2-methoxynaphthalene | HCID 3503057 | — |
Reaction Steps
6-Bromo-2-methoxynaphthalene (5.9 g, 24.81 mmol, 1 eq) and NBS (4.41, 24.81 mmol, 1 eq) are boiled in 50 ml of THF under reflux for 2 h. After washing with 1 N HCl, the organic phase is dried over magnesium sulfate, filtered and concentrated in vacuum on a rotary evaporator. The compound is obtained in quantitative yield (7.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546392B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-7529570b0a404868bf016225143e0a81 |
| Source note | uspto-grants-2013_10 |