Lithium Hydroxide → HCID 59443455, compound

Participants

Reaction Steps

Lithium hydroxide (407.7 mg, 9.94 mmol, 6 eq) is added to a solution, cooled at 0° C., of (E)-3-(2-methoxy-6-(3-methoxyphenyl)naphthalene-1-yl)acrylic acid ethyl ester (600 mg, 1.66 mmol, 1 eq) in a mixture of THF/water 3/1 (20 ml), and the reaction mixture is boiled under reflux over night. The solvent is removed in vacuum on a rotary evaporator, and 2 N HCl is added to the residue. This phase is extracted with dichloromethane. The combined organic phases are dried over magnesium sulfate, filtered and concentrated in vacuum on a rotary evaporator. The residual solid is the desired product (quantitative yield, 554 mg).

Provenance & Evidence