反应详情

温度

80 °C

To a solution of 2-(4-methoxyphenyl)malondialdehyde (797 mg, 4.48 mmol, 1 eq) in 20 ml of ethanol are added m-anisidine (551 mg, 4.48 mmol, 1 eq) and 10 ml of conc. HCl. The reaction mixture is stirred at 80° C. for 3 days, and after cooling to RT, the reaction is stopped by adding a 10% sodium carbonate solution. The mixture is extracted with dichloromethane, and the organic phase is dried over MgSO4, filtered, and the solvent is removed in vacuum on a rotary evaporator. After purification by column chromatography with hexane/ethyl acetate as the eluent, the product was obtained in a yield of 19% (221 mg).

1. temperatureafter cooling to RT
2. extractionThe mixture is extracted with dichloromethane
3. dry with materialthe organic phase is dried over MgSO4
4. filtrationfiltered
5. customthe solvent is removed in vacuum on a rotary evaporator
6. customAfter purification by column chromatography with hexane/ethyl acetate as the eluent
7. customthe product was obtained in a yield of 19% (221 mg)