6-Bromo-2-naphthalenol → 6-Phenylnaphthalen-2-ol

HRID 1035604ノート

反応式

HRID 1035604 の反応式
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]2.[C:13]1(OB(O)O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]3)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

3

反応物 2

HCID 271446-Bromo-2-naphthalenolHCID 78412Phenyl dihydrogen orthoborate

生成物 1

HCID 101251826-Phenylnaphthalen-2-ol収率 87%

実験手順

The compound is prepared by the reaction of 6-bromo-2-naphthol (500 mg, 2.24 mmol, 1 eq) with phenylboric acid (1 eq) according to method A within 20 h. Purification by column chromatography with hexane/ethyl acetate 7/3 as the eluent yields the desired product in a yield of 87%, 429 mg.

後処理

  1. customPurification by column chromatography with hexane/ethyl acetate 7/3 as the eluent

出典と根拠

ORDレコード
ord-5424f8bc91594aac919514a62e3cbcc2
出典データセット
uspto-grants-2013_10
特許番号
US08546392B2

反応ノート

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