2-Bromonaphthalene → 3-(2-Naphthyl)phenol

HRID 1035605Notes

Reaction equation

HRID 1035605 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[OH:12][C:13]1[CH:14]=[C:15](OB(O)O)[CH:16]=[CH:17][CH:18]=1>>[CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[C:17]1[CH:18]=[C:13]([OH:12])[CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 113722-BromonaphthaleneHCID 217081833-Hydroxyphenylboric acid

Product 1

HCID 123164063-(2-Naphthyl)phenolYield 47%

Procedure

The compound is prepared by the reaction of 2-bromonaphthalene (303 mg, 1.46 mmol, 1 eq) with 3-hydroxyphenylboric acid (242 mg, 1.76 mmol, 1.2 eq) according to method A within 18 h. Purification by column chromatography with dichloromethane as the eluent yields the desired product in a yield of 47%, 152 mg.

Workup

  1. customPurification by column chromatography with dichloromethane as the eluent

Sources & evidence

ORD record
ord-9e869aec416448c1957e28defc419775
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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