1,6-Dibromo-2-methoxynaphthalene → HCID 59443446, compound

HRID 1035611Notes

Reaction equation

HRID 1035611 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][C:8](Br)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:13][CH3:14].[CH3:15][O:16][C:17]1[CH:18]=[C:19](OB(O)O)[CH:20]=[CH:21][CH:22]=1>>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:21]3[CH:20]=[CH:19][CH:18]=[C:17]([O:16][CH3:15])[CH:22]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:13][CH3:14]

Participants

3

Reactant 2

HCID 35030571,6-Dibromo-2-methoxynaphthaleneHCID 221738233-Methoxyphenylboric acid

Product 1

HCID 59443446HCID 59443446, compoundYield 81%

Procedure

The compound is prepared by the reaction of 1,6-dibromo-2-methoxy-naphthalene (5.75 g, 18.20 mmol, 1 eq) with 3-methoxyphenylboric acid (2.77 g, 18.20 mmol, 1 eq) according to method A. Purification by column chromatography with hexane as the eluent yielded the desired compound in a yield of 81%, 5.1 g.

Workup

  1. customPurification by column chromatography with hexane as the eluent

Sources & evidence

ORD record
ord-cec8634c05b8452995dbcc8c25b65f70
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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