HCID 24950391, compound → HCID 25069763, compound

HRID 1035613Notes

Reaction equation

HRID 1035613 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:19].[CH3:20][O:21][C:22]1[N:27]=[CH:26][C:25](OB(O)O)=[CH:24][CH:23]=1>>[OH:19][C:3]1[CH:2]=[C:11]([C:6]2[CH:5]=[C:17]3[C:12](=[CH:8][CH:7]=2)[C:13]([C:25]2[CH:26]=[N:27][C:22]([O:21][CH3:20])=[CH:23][CH:24]=2)=[C:14]([OH:18])[CH:15]=[CH:16]3)[CH:10]=[CH:9][CH:4]=1

Participants

3

Reactant 2

HCID 24950391HCID 24950391, compoundHCID 67315140HCID 67315140, compound

Product 1

HCID 25069763HCID 25069763, compoundYield 84%

Procedure

The compound is prepared by the reaction of 1-bromo-6-(3-hydroxyphenyl)-naphthalene-2-ol (100 mg, 0.32 mmol, 1 eq) with 6-methoxypyridin-3-ylboric acid (48.6 mg, 0.32 mmol, 1 eq) according to method A in 3 h. Purification by column chromatography with hexane/ethyl acetate 8/2 yields the desired compound in a yield of 84%, 92 mg.

Workup

  1. customPurification by column chromatography with hexane/ethyl acetate 8/2

Sources & evidence

ORD record
ord-1b7144d5048f4d14afd27fa5fd46bc68
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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