HCID 24950391, compound → HCID 25074168, compound

HRID 1035615Notes

Reaction equation

HRID 1035615 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=3)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:19].[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][C:29](OB(O)O)=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[OH:18][C:14]1[CH:13]=[C:12]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[C:4]([C:29]2[CH:28]=[CH:27][C:26]([N:23]4[CH2:22][CH2:21][O:20][CH2:25][CH2:24]4)=[CH:31][CH:30]=2)=[C:3]([OH:19])[CH:2]=[CH:11]3)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 24950391HCID 24950391, compoundHCID 54337551HCID 54337551, compound

Product 1

HCID 25074168HCID 25074168, compoundYield 7%

Procedure

The compound is prepared by the reaction of 1-bromo-6-(3-hydroxyphenyl)-naphthalene-2-ol (150 mg, 0.48 mmol, 1 eq) with 4-morpholinophenylboric acid (98.6 mg, 0.48 mmol, 1 eq) according to method A in 21 h. Purification by column chromatography with dichloromethane/methanol 99/1 yields the desired compound in a yield of 7%, 13 mg.

Workup

  1. customPurification by column chromatography with dichloromethane/methanol 99/1

Sources & evidence

ORD record
ord-8e6e3b2c639c427c876b776f17bcefbb
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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