HCID 25035958, compound → HCID 59443480, compound

HRID 1035618Notes

Reaction equation

HRID 1035618 reaction equation
Br[C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:17][O:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=3)[CH:25]=2)[C:20]=1OB(O)O>>[CH3:17][O:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=3)[CH:25]=2)[C:20]=1[C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 25035958HCID 25035958, compoundHCID 68482452HCID 68482452, compound

Product 1

HCID 59443480HCID 59443480, compoundYield 14%

Procedure

The compound is prepared by the reaction of 3-bromo-N-(thiazol-2-yl)benzenesulfonamide (88.8 mg, 0.28 mmol, 1 eq) with 2-methoxy-6-(3-methoxyphenyl)-naphthalene-1-ylboric acid (100 mg, 0.36 mmol, 1.3 eq) according to method C. Purification by column chromatography with dichloromethane/methanol 95/5 yields the desired compound in a yield of 14%, 19 mg.

Workup

  1. customPurification by column chromatography with dichloromethane/methanol 95/5

Sources & evidence

ORD record
ord-acc50a00d3ce4166b6e3e19895760671
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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