Methylamine → HCID 59443462, compound

HRID 1035630Notes

Reaction equation

HRID 1035630 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1/[CH:21]=[CH:22]/[C:23]([OH:25])=O.[CH3:26][NH2:27]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1/[CH:21]=[CH:22]/[C:23]([NH:27][CH3:26])=[O:25]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 59443455HCID 59443455, compound

Product 1

HCID 59443462HCID 59443462, compound

Procedure

The compound was prepared by reaction of (E)-3-(2-methoxy-6-(3-methoxyphenyl)naphthalene-1-yl)acrylic acid (200 mg, 0.60 mmol, 1 eq) with 33% methylamine (1 eq) according to method D. Purification by column chromatography was not necessary. The desired compound was obtained in quantitative yield.

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-cbbe27d755d043f5b277c651b828e178
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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