Methylamine → HCID 59443449, compound

HRID 1035632Notes

Reaction equation

HRID 1035632 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21]([OH:23])=O.[CH3:24][NH2:25]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21]([NH:25][CH3:24])=[O:23]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 594434812-Methoxy-6-(3-methoxyphenyl)-1-naphthoic acid

Product 1

HCID 59443449HCID 59443449, compound

Procedure

The compound was prepared by reaction of 2-methoxy-6-(3-methoxyphenyl)-1-naphthoic acid (300 mg, 0.97 mmol, 1 eq) with 33% methylamine (1 eq) according to method D. Purification by column chromatography was not necessary. The desired compound was obtained in quantitative yield (311 mg).

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-6a091a732e494de3b181d9abef7595bc
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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