Aniline → HCID 59443482, compound

HRID 1035633Notes

Reaction equation

HRID 1035633 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21](O)=[O:22].[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22]

Participants

3

Reactant 2

HCID 6115AnilineHCID 594434812-Methoxy-6-(3-methoxyphenyl)-1-naphthoic acid

Product 1

HCID 59443482HCID 59443482, compoundYield 85%

Procedure

The compound was prepared by reaction of 2-methoxy-6-(3-methoxyphenyl)-1-naphthoic acid (300 mg, 0.97 mmol, 1 eq) with aniline (1 eq) according to method D. Purification by column chromatography with hexane/ethyl acetate 2/1 as the eluent yielded the desired compound in a yield of 85%, 316 mg.

Workup

  1. customPurification by column chromatography with hexane/ethyl acetate 2/1 as the eluent

Sources & evidence

ORD record
ord-22625dd9c772478c8865cba6c2e207ce
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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