1,3,4-Thiadiazole, 2-amino-5-methyl- → 2-Methoxy-6-(3-methoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-1-naphthamide

HRID 1035636Notes

Reaction equation

HRID 1035636 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21]([OH:23])=O.[NH2:24][C:25]1[S:26][C:27]([CH3:30])=[N:28][N:29]=1>CCOCC>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[CH:9]=2)[C:4]=1[C:21]([NH:24][C:25]1[S:26][C:27]([CH3:30])=[N:28][N:29]=1)=[O:23]

Participants

4

Reactant 2

HCID 669491,3,4-Thiadiazole, 2-amino-5-methyl-HCID 59443481HCID 59443481, compound

Product 1

HCID 594434762-Methoxy-6-(3-methoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-1-naphthamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound was prepared by reaction of 2-methoxy-6-(3-methoxyphenyl)-1-naphthoic acid (450 mg, 1.46 mmol, 1 eq) with 2-amino-5-methyl-1,3,4-thiadiazole (0.6 eq) according to method E. Characterization of the compound was not effected. The raw product was directly employed for ether cleavage.

Sources & evidence

ORD record
ord-13c911293eaf4529b06fe5f7c0e34114
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

Loading…