Boron tribromide → HCID 24827434, compound

HRID 1035638Notes

Reaction equation

HRID 1035638 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18]C)[CH:13]=1)=[CH:6]2.B(Br)(Br)Br>>[OH:18][C:14]1[CH:13]=[C:12]([C:7]2[NH:8][C:9]3[C:5]([CH:6]=2)=[CH:4][C:3]([OH:2])=[CH:11][CH:10]=3)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 13408303HCID 13408303, compound

Product 1

HCID 24827434HCID 24827434, compoundYield 76%

Procedure

The compound is prepared by reaction of 5-methoxy-2-(3-methoxyphenyl)-1H-indole (89 mg, 0.35 mmol, 1 eq) with boron tribromide (2.1 ml, 2.1 mmol, 6 eq) according to method G. Purification by preparative thin-layer chromatography with hexane/ethyl acetate 4/6 yields the desired product in a yield of 76%, 60 mg.

Workup

  1. customPurification by preparative thin-layer chromatography with hexane/ethyl acetate 4/6

Sources & evidence

ORD record
ord-c0d56c57fa9d493daca45d1c1392f9e5
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

Loading…