Aluminum(III) Chloride → HCID 24827431, compound

HRID 1035644Notes

Reaction equation

HRID 1035644 reaction equation
C[O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19]C)[CH:15]=3)[CH:10]=2)[CH:8]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[OH:19][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([C:7]1[CH:8]=[C:3]([OH:2])[CH:4]=[N:5][CH:6]=1)[CH:18]=[CH:17]2

Participants

3

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 24827305HCID 24827305, compound

Product 1

HCID 24827431HCID 24827431, compoundYield 7%

Procedure

The compound is prepared by reaction of 3-methoxy-5-(6-methoxynaphthalene-2-yl)pyridine (200 mg, 0.75 mmol, 1 eq) with aluminum trichloride (803 mg, 6.04 mmol, 8 eq) according to method F. Purification by column chromatography with dichloromethane/methanol 95/5 as the eluent yields the desired product in a yield of 7%, 13 mg.

Workup

  1. customPurification by column chromatography with dichloromethane/methanol 95/5 as the eluent

Sources & evidence

ORD record
ord-82fbd0efe5024f45a1eb06fbbc2ae82d
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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